Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.42 |
| ▸ | PARG | Q86W56 | 4/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | POLB | P06746 | 6/20 | 0.36 |
| ▸ | TP53 | P04637 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3255208 | 0.88 | PARG (0.48) | TDP1PARGBRAFMAPTPOLB | |
| SCHEMBL13928154 | 0.85 | PARG (0.46) | TDP1PARGBRAFMAPTPOLB | |
| SCHEMBL3254905 | 0.85 | PARG (0.45) | TDP1PARGBRAFMAPTPOLB | |
| SCHEMBL13928156 | 0.83 | TDP1 (0.43) | TDP1PARGBRAFMAPTPOLB | |
| SCHEMBL3252622 | 0.83 | TDP1 (0.54) | TDP1PARGBRAFMAPTPOLB | |
| SCHEMBL3250747 | 0.83 | PARG (0.43) | TDP1PARGBRAFMAPTPOLB | |
| SCHEMBL3245470 | 0.83 | PARG (0.50) | TDP1PARGBRAFMAPTPOLB | |
| SCHEMBL3251014 | 0.82 | TDP1 (0.53) | TDP1PARGBRAFMAPTPOLB | |
| SCHEMBL3253347 | 0.82 | PARG (0.42) | TDP1PARGBRAFMAPTPOLB | |
| SCHEMBL3245466 | 0.81 | PARG (0.42) | TDP1PARGBRAFMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |