Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.58 |
| ▸ | PLK3 | Q9H4B4 | 7/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | NEK2 | P51955 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13440294 | 0.94 | PLK1 (0.59) | PLK1CYP3A4PLK3CYP2C9PIK3CD | |
| SCHEMBL3259430 | 0.94 | PLK1 (0.59) | PLK1CYP3A4PLK3CYP2C9PIK3CD | |
| SCHEMBL3603049 | 0.93 | PLK1 (0.60) | PLK1CYP3A4PLK3CYP2C9PIK3CD | |
| SCHEMBL13440290 | 0.92 | PLK1 (0.69) | PLK1CYP3A4PLK3CYP2C9PIK3CD | |
| SCHEMBL3255298 | 0.92 | PLK1 (0.69) | PLK1CYP3A4PLK3CYP2C9PIK3CD | |
| SCHEMBL3268381 | 0.88 | PLK1 (0.57) | PLK1CYP3A4PLK3CYP2C9PIK3CD | |
| SCHEMBL3255418 | 0.88 | PLK1 (0.57) | PLK1CYP3A4PLK3CYP2C9PIK3CD | |
| SCHEMBL3614751 | 0.87 | PLK1 (0.58) | PLK1CYP3A4PLK3CYP2C9PIK3CD | |
| SCHEMBL13440293 | 0.86 | PLK1 (0.66) | PLK1CYP3A4PLK3CYP2C9PIK3CD | |
| SCHEMBL3255851 | 0.86 | PLK1 (0.55) | PLK1CYP3A4PLK3CYP2C9PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032563-B1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON PLK | GLAXOSMITHKLINE LLC (US) | 2010-06-02 | — | — | EP | disclosed |