Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 4/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | PRKDC | P78527 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2959517 | 0.85 | IGF1R (0.45) | IGF1REGFRERBB2SRCATR | |
| SCHEMBL2967036 | 0.79 | IGF1R (0.59) | IGF1REGFRERBB2 | |
| SCHEMBL2959491 | 0.77 | IGF1R (0.59) | IGF1REGFRERBB2 | |
| SCHEMBL2959065 | 0.76 | SRC (0.60) | IGF1REGFRERBB2SRCFYN | |
| SCHEMBL2957993 | 0.76 | IGF1R (0.62) | IGF1REGFRERBB2 | |
| SCHEMBL2956433 | 0.75 | IGF1R (0.60) | IGF1REGFRERBB2KDR | |
| SCHEMBL2956438 | 0.75 | IGF1R (0.60) | IGF1REGFRERBB2KDR | |
| SCHEMBL2965040 | 0.75 | IGF1R (0.60) | IGF1REGFRERBB2KDR | |
| SCHEMBL2955758 | 0.75 | IGF1R (0.64) | IGF1REGFRERBB2SRCATR | |
| SCHEMBL2959425 | 0.74 | IGF1R (0.63) | IGF1REGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772231-B2 | Substituted pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors | ABBOTT LABORATORIES (US) | 2010-08-10 | — | — | US | claimed |