Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3256404 | 1.00 | NPC1 (0.41) | NPC1CNR1ADRB3GABRA1ADRA2B | |
| SCHEMBL1339165 | 0.91 | NPC1 (0.43) | NPC1CNR1CNR2 | |
| SCHEMBL1339163 | 0.91 | NPC1 (0.43) | NPC1CNR1CNR2 | |
| SCHEMBL1338115 | 0.85 | NPC1 (0.48) | NPC1CNR1ADRB3GABRA1ADRA2B | |
| SCHEMBL1339497 | 0.76 | NPC1 (0.37) | NPC1CNR1GABRA1CNR2 | |
| SCHEMBL1339295 | 0.75 | NPC1 (0.37) | NPC1CNR1GABRA1CNR2 | |
| SCHEMBL1339178 | 0.75 | NPC1 (0.36) | NPC1CNR1GABRA1CNR2 | |
| SCHEMBL1340547 | 0.75 | NPC1 (0.36) | NPC1CNR1GABRA1CNR2 | |
| SCHEMBL1336876 | 0.74 | MAPT (0.44) | NPC1CNR1CNR2 | |
| SCHEMBL1336878 | 0.74 | MAPT (0.44) | NPC1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-B1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-07-21 | — | — | EP | disclosed |