Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 14/20 | 0.48 |
| ▸ | GAB1 | Q13480 | 5/20 | 0.48 |
| ▸ | IRS1 | P35568 | 3/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3256635 | 0.87 | AKT1 (0.51) | AKT1GAB1IRS1FFAR4ALDH1A1 | |
| SCHEMBL3256711 | 0.81 | AKT1 (0.56) | AKT1GAB1IRS1FFAR4PDPK1 | |
| SCHEMBL3251168 | 0.81 | MAPT (0.51) | — | |
| SCHEMBL3253214 | 0.79 | AKT1 (0.46) | AKT1GAB1IRS1FFAR4PDPK1 | |
| SCHEMBL3256918 | 0.77 | AKT1 (0.47) | AKT1GAB1IRS1FFAR4ALDH1A1 | |
| SCHEMBL7093105 | 0.77 | AKT1 (0.47) | AKT1GAB1IRS1FFAR4PDPK1 | |
| SCHEMBL4892513 | 0.76 | AKT1 (0.47) | AKT1GAB1FFAR4ALDH1A1 | |
| SCHEMBL3251192 | 0.76 | AKT1 (0.48) | AKT1GAB1IRS1FFAR4PDPK1 | |
| SCHEMBL3248288 | 0.75 | AKT1 (0.45) | AKT1GAB1IRS1FFAR4PDPK1 | |
| SCHEMBL3251447 | 0.75 | AKT1 (0.45) | AKT1GAB1IRS1FFAR4PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2010-05-26 | — | — | EP | claimed |