Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 7/20 | 0.40 |
| ▸ | NEK2 | P51955 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13440387 | 0.91 | PLK1 (0.50) | PLK1CYP3A4CYP2C9PLK3NEK2 | |
| SCHEMBL3258921 | 0.91 | PLK1 (0.50) | PLK1CYP3A4CYP2C9PLK3NEK2 | |
| SCHEMBL3257571 | 0.86 | PLK1 (0.44) | PLK1CYP3A4CYP2C9PLK3NEK2 | |
| SCHEMBL13440384 | 0.86 | PLK1 (0.44) | PLK1CYP3A4CYP2C9PLK3NEK2 | |
| SCHEMBL13440388 | 0.82 | PLK1 (0.60) | PLK1CYP3A4CYP2C9PLK3NEK2 | |
| SCHEMBL3250730 | 0.82 | PLK1 (0.60) | PLK1CYP3A4CYP2C9PLK3NEK2 | |
| SCHEMBL3257786 | 0.80 | PLK1 (0.62) | PLK1CYP3A4CYP2C9PLK3NEK2 | |
| SCHEMBL13440210 | 0.80 | PLK1 (0.57) | PLK1CYP3A4CYP2C9PLK3NEK2 | |
| SCHEMBL3248782 | 0.80 | PLK1 (0.57) | PLK1CYP3A4CYP2C9PLK3NEK2 | |
| SCHEMBL3257355 | 0.80 | PLK1 (0.65) | PLK1CYP3A4CYP2C9PLK3NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032563-B1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON PLK | GLAXOSMITHKLINE LLC (US) | 2010-06-02 | — | — | EP | disclosed |