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SCHEMBL3258147

SCHEMBL3258147

Cc1cc(=O)oc2cc(NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)OC(C)(C)C)ccc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA12 O43570 3/20 0.56
▸ CA1 P00915 3/20 0.56
▸ CA9 Q16790 3/20 0.56
▸ KDM4E B2RXH2 5/20 0.52
▸ ALDH1A1 P00352 5/20 0.52
▸ HPGD P15428 4/20 0.52
▸ HSD17B10 Q99714 2/20 0.52
▸ KMT2A Q03164 2/20 0.52
▸ MEN1 O00255 1/20 0.52
▸ GLA P06280 1/20 0.49
▸ GAA P10253 1/20 0.49
▸ SIRT5 Q9NXA8 1/20 0.46
▸ RAB9A P51151 3/20 0.46
▸ NPC1 O15118 2/20 0.46
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ TDP1 Q9NUW8 1/20 0.45
▸ HDAC4 P56524 2/20 0.45
▸ HDAC1 Q13547 2/20 0.45
▸ CASP3 P42574 1/20 0.45
▸ SENP8 Q96LD8 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11442830 1.00 CA12 (0.56) CA12CA1CA9KDM4EALDH1A1
SCHEMBL29544308 1.00 CA12 (0.56) CA12CA1CA9KDM4EALDH1A1
SCHEMBL29947213 0.94 CA12 (0.64) CA12CA1CA9KDM4EALDH1A1
SCHEMBL29758957 0.94 CA12 (0.64) CA12CA1CA9KDM4EALDH1A1
SCHEMBL14725053 0.94 CA12 (0.64) CA12CA1CA9KDM4EALDH1A1
SCHEMBL11215355 0.88 CA1 (0.49) CA12CA1CA9KDM4EALDH1A1
SCHEMBL29791072 0.87 KDM4E (0.50) KDM4EALDH1A1HPGDHSD17B10KMT2A
SCHEMBL11463028 0.87 KDM4E (0.57) CA12CA1CA9KDM4EALDH1A1
Hydrochloric Acid SCHEMBL8357861 0.86 KDM4E (0.49) KDM4EALDH1A1HPGDHSD17B10KMT2A
SCHEMBL11459005 0.86 KDM4E (0.56) CA12CA1CA9KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250297300-A1 DETECTION, STAGING, MONITORING AND TREATING A DISEASE OR A CONDITION Sunbird Bio, Inc. 2025-09-25 — — US disclosed
US-20250223627-A1 FLUOROGENIC SUBSTRATES FOR AMINOPEPTIDASE DETECTION IN BIOFLUIDS Sunbird Bio, Inc. 2025-07-10 — — US disclosed
US-20250215476-A1 EX VIVO PROTEASE ACTIVITY DETECTION FOR HEPATOCELLULAR CARCINOMA Sunbird Bio, Inc. 2025-07-03 — — US disclosed
US-20250197917-A1 METHOD OF PROTEASE DETECTION Sunbird Bio, Inc. 2025-06-19 — — US disclosed
US-12305217-B2 Ex vivo protease activity detection for disease detection/diagnostic, staging, monitoring and treatment Sunbird Bio, Inc. (US) 2025-05-20 — — US disclosed
US-20250110130-A1 EX VIVO PROTEASE ACTIVATION AND DETECTION Sunbird Bio, Inc. 2025-04-03 — — US disclosed
US-20250092437-A1 DISEASE DETECTION WITH COMBINATORIAL BIOMARKERS Sunbird Bio, Inc. 2025-03-20 — — US disclosed
US-20230175037-A1 EX VIVO PROTEASE ACTIVITY DETECTION FOR DISEASE DETECTION/DIAGNOSTIC, STAGING, MONITORING AND TREATMENT Sunbird Bio, Inc. 2023-06-08 — — US disclosed
US-11604193-B2 Ex vivo protease activity detection for disease detection/diagnostic, staging, monitoring and treatment GLYMPSE BIO, INC. (US) 2023-03-14 — — US disclosed
US-20220178935-A1 EX VIVO PROTEASE ACTIVITY DETECTION FOR DISEASE DETECTION/DIAGNOSTIC, STAGING, MONITORING AND TREATMENT Sunbird Bio, Inc. 2022-06-09 — — US disclosed
EP-1189630-B1 PROPHYLAXIS AND TREATMENT OF P. GINGIVALIS INFECTION UNIV SYDNEY (AU) 2010-03-03 — — EP disclosed
US-7319086-B1 Method of prophylaxis and treatment and agents useful for same UNIVERSITY OF SYDNEY (AU) 2008-01-15 — — US disclosed