Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3141975 | 0.87 | HIF1A (0.54) | MAPK1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL3258562 | 0.85 | S1PR1 (0.44) | KMT2ANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL3150326 | 0.84 | HTR2A (0.49) | MAPK1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL3136631 | 0.83 | S1PR1 (0.50) | MAPK1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL3141228 | 0.83 | NPC1 (0.53) | KMT2AMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL3150284 | 0.83 | S1PR1 (0.52) | MAPK1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL2867506 | 0.82 | S1PR1 (0.44) | MAPK1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL2865681 | 0.82 | S1PR1 (0.49) | MAPK1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL2866482 | 0.82 | S1PR1 (0.51) | MAPK1KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL13478730 | 0.82 | S1PR1 (0.51) | MAPK1KMT2AMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747196-B1 | SUBSTITUTED ARYL ACYLTHIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS INC (US) | 2010-02-10 | — | — | EP | claimed |