Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.49 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.42 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27316393 | 0.80 | TTK (0.46) | BRD4SMARCA2SMARCA4PDK2ALOX5AP | |
| SCHEMBL23638914 | 0.79 | BRD4 (0.54) | BRD4SMARCA2SMARCA4PDK2ALOX5AP | |
| SCHEMBL10094625 | 0.79 | BRD4 (0.54) | BRD4SMARCA2SMARCA4PDK2ALOX5AP | |
| SCHEMBL10094326 | 0.79 | BRD4 (0.50) | BRD4SMARCA2SMARCA4PDK2ALOX5AP | |
| SCHEMBL22917029 | 0.78 | BRD4 (0.53) | BRD4SMARCA2SMARCA4PDK2ALOX5AP | |
| SCHEMBL10544187 | 0.78 | SMARCA2 (0.60) | BRD4SMARCA2SMARCA4PDK2ALOX5AP | |
| SCHEMBL9388340 | 0.78 | BRD4 (0.53) | BRD4SMARCA2SMARCA4PDK2ALOX5AP | |
| SCHEMBL21379805 | 0.78 | BRD4 (0.53) | BRD4SMARCA2SMARCA4PDK2ALOX5AP | |
| SCHEMBL21142531 | 0.78 | BRD4 (0.53) | BRD4SMARCA2SMARCA4PDK2ALOX5AP | |
| SCHEMBL16968461 | 0.78 | SMARCA2 (0.68) | BRD4SMARCA2SMARCA4PDK2ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815855-B2 | N-sulphonylpyrroles and their use as histone deacetylase inhibitors | 4SC AG (DE) | 2014-08-26 | — | — | US | disclosed |
| US-20100074862-A1 | N-SULPHONYLPYRROLES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | MAIER THOMAS | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100074862-A1 | N-SULPHONYLPYRROLES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC2 | BRD4 44/4885SMARCA2 227/4885SMARCA4 209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.