Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | LCK | P06239 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3258517 | 0.97 | AURKA (0.38) | AURKATNK2EGFRLCKJAK2 | |
| SCHEMBL2180431 | 0.90 | CHEK1 (0.38) | AURKATNK2EGFRLCKJAK2 | |
| SCHEMBL2180134 | 0.87 | CHEK1 (0.39) | AURKATNK2EGFRLCKJAK2 | |
| SCHEMBL12409654 | 0.87 | CHEK1 (0.39) | AURKATNK2EGFRLCKJAK2 | |
| SCHEMBL2178584 | 0.86 | AURKA (0.36) | AURKATNK2EGFRLCKJAK2 | |
| SCHEMBL2178586 | 0.85 | MERTK (0.36) | AURKATNK2EGFRLCKJAK2 | |
| SCHEMBL2180183 | 0.83 | AURKA (0.37) | AURKATNK2EGFRLCKJAK2 | |
| SCHEMBL12409631 | 0.83 | AURKA (0.37) | AURKATNK2EGFRLCKJAK2 | |
| SCHEMBL2180189 | 0.83 | AURKA (0.36) | AURKATNK2EGFRLCKJAK2 | |
| SCHEMBL4696958 | 0.80 | KDM4E (0.58) | AURKATNK2EGFRLCKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158206-A1 | SUBSTITUTED FUROPYRIMIDINES AND USE THEREOF | Bayer Schering Pharma Aktiengesellschaft (DE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008155016-A1 | SUBSTITUTED FUROPYRIMIDINES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-12-24 | — | — | WO | disclosed |