Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.61 |
| ▸ | JAK3 | P52333 | 16/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 13/20 | 0.56 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13535979 | 0.92 | JAK2 (0.64) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535729 | 0.91 | JAK2 (0.60) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535985 | 0.89 | JAK2 (0.58) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13536016 | 0.89 | JAK2 (0.59) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535788 | 0.87 | JAK2 (0.75) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535698 | 0.87 | JAK2 (0.74) | JAK2JAK3PTK2 | |
| SCHEMBL13535733 | 0.87 | JAK2 (0.68) | JAK2JAK3PTK2 | |
| SCHEMBL13536007 | 0.85 | JAK2 (0.54) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13536158 | 0.84 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3224332 | 0.83 | JAK2 (0.71) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |