Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.68 |
| ▸ | JAK3 | P52333 | 1/20 | 0.68 |
| ▸ | RHOA | P61586 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 5/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CDC25B | P30305 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2640343 | 0.82 | JAK2 (1.00) | JAK2JAK3MEN1KMT2AHTT | |
| SCHEMBL30633056 | 0.77 | RHOA (0.93) | RHOANPC1RAB9AMEN1KMT2A | |
| SCHEMBL26135613 | 0.77 | RHOA (0.93) | RHOANPC1RAB9AMEN1KMT2A | |
| SCHEMBL12970803 | 0.75 | JAK2 (0.65) | JAK2JAK3SYK | |
| SCHEMBL20242755 | 0.73 | RHOA (0.59) | RHOANPC1RAB9AMEN1KMT2A | |
| SCHEMBL5317913 | 0.72 | JAK2 (0.74) | JAK2JAK3NPC1RAB9AMEN1 | |
| 3-Phenylamino Benzoic Acid SCHEMBL4345076 | 0.72 | RHOA (0.77) | RHOARAB9AMEN1KMT2AHTT | |
| SCHEMBL11963751 | 0.72 | RHOA (0.67) | RHOANPC1RAB9AMEN1KMT2A | |
| SCHEMBL21925297 | 0.72 | RHOA (0.77) | RHOANPC1RAB9AMEN1KMT2A | |
| SCHEMBL28238119 | 0.72 | RHOA (0.82) | RHOANPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |