Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 0.82 |
| ▸ | BRD4 | O60885 | 3/20 | 0.64 |
| ▸ | PDXK | O00764 | 1/20 | 0.64 |
| ▸ | WEE1 | P30291 | 1/20 | 0.64 |
| ▸ | NEK3 | P51956 | 1/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.64 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.64 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.64 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.64 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13434811 | 1.00 | PLK1 (0.82) | PLK1BRD4PDXKWEE1NEK3 | |
| SCHEMBL3261668 | 1.00 | PLK1 (0.82) | PLK1BRD4PDXKWEE1NEK3 | |
| SCHEMBL3265172 | 0.95 | PLK1 (0.88) | PLK1BRD4PDXKWEE1NEK3 | |
| SCHEMBL3265169 | 0.95 | PLK1 (0.88) | PLK1BRD4PDXKWEE1NEK3 | |
| SCHEMBL13434810 | 0.95 | PLK1 (0.88) | PLK1BRD4PDXKWEE1NEK3 | |
| SCHEMBL13434813 | 0.94 | PLK1 (0.79) | PLK1BRD4PDXKWEE1NEK3 | |
| SCHEMBL3261762 | 0.94 | PLK1 (0.79) | PLK1BRD4PDXKWEE1NEK3 | |
| SCHEMBL3261760 | 0.94 | PLK1 (0.79) | PLK1BRD4PDXKWEE1NEK3 | |
| SCHEMBL3488810 | 0.93 | PLK1 (0.82) | PLK1BRD4PDXKWEE1NEK3 | |
| SCHEMBL3488814 | 0.93 | PLK1 (0.82) | PLK1BRD4PDXKWEE1NEK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075973-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-25 | — | — | US | disclosed |
| WO-2010025073-A1 | DIHYDROIMIDAZO [ 1, 5-F] PTERIDINES AS POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075973-A1 | POLO-LIKE KINASE INHIBITORS | PLK2, PLK4, PLK1 | PLK1 3/4885BRD4 1842/4885PDXK 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.