Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 13/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.65 |
| ▸ | PRKCG | P05129 | 1/20 | 0.65 |
| ▸ | LYN | P07948 | 1/20 | 0.65 |
| ▸ | PRKACA | P17612 | 1/20 | 0.65 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.65 |
| ▸ | AKT1 | P31749 | 1/20 | 0.65 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.65 |
| ▸ | CLK2 | P49760 | 1/20 | 0.65 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.65 |
| ▸ | PRKX | P51817 | 1/20 | 0.65 |
| ▸ | NEK4 | P51957 | 1/20 | 0.65 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.65 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.65 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284196 | 0.91 | AURKB (0.64) | AURKBDYRK1AROCK2MAP4K4PRKCG | |
| SCHEMBL13457460 | 0.90 | AURKB (0.57) | AURKBDYRK1AROCK2MAP4K4PRKCG | |
| SCHEMBL13457008 | 0.89 | AURKB (0.50) | AURKBDYRK1AROCK2MAP4K4PRKCG | |
| SCHEMBL13457500 | 0.87 | AURKB (0.61) | AURKBDYRK1AROCK2MAP4K4PRKCG | |
| SCHEMBL13457416 | 0.85 | USP30 (0.51) | AURKBDYRK1AROCK2MAP4K4PRKCG | |
| SCHEMBL13457059 | 0.83 | AURKB (0.51) | AURKBDYRK1AROCK2MAP4K4PRKCG | |
| SCHEMBL13457192 | 0.83 | PIK3CA (0.49) | AURKBDYRK1AROCK2MAP4K4PRKCG | |
| SCHEMBL4283666 | 0.80 | AURKB (0.63) | AURKBDYRK1AROCK2MAP4K4PRKCG | |
| SCHEMBL4283665 | 0.80 | MAP4K4 (0.78) | AURKBDYRK1AROCK2MAP4K4PRKCG | |
| SCHEMBL4286537 | 0.79 | CLK4 (1.00) | AURKBDYRK1AROCK2MAP4K4PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010024903-A1 | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-03-04 | — | — | WO | disclosed |
| WO-2010024903-A1 | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-03-04 | — | — | WO | disclosed |