Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.55 |
| ▸ | JAK1 | P23458 | 9/20 | 0.52 |
| ▸ | JAK3 | P52333 | 5/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13535632 | 0.89 | JAK2 (0.59) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL13536181 | 0.88 | JAK1 (0.54) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL13535870 | 0.87 | JAK2 (0.57) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL13536065 | 0.86 | JAK2 (0.70) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL13535788 | 0.86 | JAK2 (0.75) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL13535874 | 0.86 | JAK2 (0.54) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL13536215 | 0.86 | JAK2 (0.51) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL13535617 | 0.85 | JAK2 (0.55) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL13535817 | 0.85 | JAK2 (0.51) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL13535642 | 0.85 | JAK2 (0.60) | JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |