Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.48 |
| ▸ | JAK3 | P52333 | 15/20 | 0.46 |
| ▸ | JAK1 | P23458 | 8/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | FGR | P09769 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | SIK1 | P57059 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2160850 | 0.86 | JAK2 (0.52) | JAK2JAK3JAK1AURKAABL1 | |
| SCHEMBL2161216 | 0.86 | JAK2 (0.52) | JAK2JAK3JAK1AURKAABL1 | |
| SCHEMBL13494475 | 0.85 | JAK2 (0.54) | JAK2JAK3JAK1AURKAABL1 | |
| SCHEMBL13494382 | 0.81 | JAK2 (0.58) | JAK2JAK3JAK1AURKAABL1 | |
| SCHEMBL13494396 | 0.81 | JAK2 (0.74) | JAK2JAK3JAK1AURKAABL1 | |
| SCHEMBL13494460 | 0.81 | JAK2 (0.58) | JAK2JAK3JAK1AURKAABL1 | |
| SCHEMBL13494383 | 0.78 | JAK2 (0.50) | JAK2JAK3JAK1AURKAABL1 | |
| SCHEMBL12354831 | 0.77 | JAK2 (0.61) | JAK2JAK3JAK1AURKAABL1 | |
| SCHEMBL2240916 | 0.77 | JAK2 (0.61) | JAK2JAK3JAK1AURKAABL1 | |
| SCHEMBL2247732 | 0.77 | JAK2 (0.61) | JAK2JAK3JAK1AURKAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020810-A1 | 2-(IMIDAZ0LYLAMIN0)-PYRIDINE DERIVATIVES AND THEIR USE AS JAK KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-02-25 | — | — | WO | disclosed |