Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K2 | P36507 | 20/20 | 0.72 |
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | ACTR3 | P61158 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26114935 | 0.84 | MAP2K2 (0.64) | MAP2K2MAP2K1CHRM2CHRM1BRAF | |
| SCHEMBL189188 | 0.84 | MAP2K1 (1.00) | MAP2K2MAP2K1CHRM2CHRM1BRAF | |
| SCHEMBL29413551 | 0.84 | MAP2K1 (1.00) | MAP2K2MAP2K1CHRM2CHRM1BRAF | |
| Hydrochloric Acid SCHEMBL29413470 | 0.83 | MAP2K1 (0.98) | MAP2K2MAP2K1CHRM2CHRM1BRAF | |
| SCHEMBL30220857 | 0.81 | MAP2K1 (0.82) | MAP2K2MAP2K1CHRM2CHRM1BRAF | |
| SCHEMBL4997116 | 0.81 | MAP2K1 (0.82) | MAP2K2MAP2K1CHRM2CHRM1BRAF | |
| SCHEMBL188585 | 0.81 | MAP2K1 (0.82) | MAP2K2MAP2K1CHRM2CHRM1BRAF | |
| SCHEMBL189474 | 0.81 | MAP2K1 (0.64) | MAP2K2MAP2K1CHRM2CHRM1BRAF | |
| SCHEMBL31498828 | 0.80 | MAP2K1 (0.62) | MAP2K2MAP2K1CHRM2CHRM1BRAF | |
| SCHEMBL4860627 | 0.80 | MAP2K1 (0.74) | MAP2K2MAP2K1CHRM2CHRM1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075947-A1 | Methods of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075947-A1 | Methods of Using PI3K and MEK Modulators | PIK3CA, PIK3CD, PIK3R1 | MAP2K2 51/4885MAP2K1 65/4885CHRM2 4873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.