Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 15/20 | 0.54 |
| ▸ | JAK2 | O60674 | 13/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.54 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13535941 | 0.91 | JAK1 (0.49) | JAK1JAK2JAK3IKBKBRIPK2 | |
| SCHEMBL13535940 | 0.90 | JAK1 (0.58) | JAK1JAK2TYK2 | |
| SCHEMBL13536025 | 0.88 | JAK2 (0.56) | JAK1JAK2JAK3IKBKBRIPK2 | |
| SCHEMBL13535779 | 0.88 | JAK1 (0.50) | JAK1JAK2JAK3IKBKBRIPK2 | |
| SCHEMBL3594593 | 0.86 | JAK2 (0.75) | JAK1JAK2JAK3IKBKBRIPK2 | |
| SCHEMBL3262635 | 0.86 | JAK1 (0.62) | JAK1JAK2JAK3IKBKBRIPK2 | |
| SCHEMBL13535939 | 0.86 | JAK1 (0.62) | JAK1JAK2TYK2 | |
| SCHEMBL13536233 | 0.85 | JAK2 (0.61) | JAK1JAK2JAK3IKBKBRIPK2 | |
| SCHEMBL13535768 | 0.84 | JAK1 (0.72) | JAK1JAK2JAK3IKBKBRIPK2 | |
| SCHEMBL13535705 | 0.84 | JAK1 (0.49) | JAK1JAK2JAK3IKBKBRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010187-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010187-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |