Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144134 | 1.00 | CYP2C19 (0.44) | CYP2C19FLT3YTHDC1ALDH1A1KMT2A | |
| SCHEMBL2144446 | 0.90 | CYP2C19 (0.45) | CYP2C19FLT3YTHDC1ALDH1A1KMT2A | |
| SCHEMBL30124718 | 0.84 | CYP1A2 (0.46) | CYP2C19YTHDC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL1844354 | 0.81 | CYP1A2 (0.41) | CYP2C19FLT3YTHDC1ALDH1A1KMT2A | |
| SCHEMBL18307733 | 0.81 | CYP2C19 (0.42) | CYP2C19FLT3YTHDC1ALDH1A1KMT2A | |
| SCHEMBL25431553 | 0.81 | CYP2C19 (0.39) | CYP2C19FLT3YTHDC1ALDH1A1KMT2A | |
| SCHEMBL18309163 | 0.81 | CYP2C19 (0.42) | CYP2C19FLT3YTHDC1ALDH1A1KMT2A | |
| SCHEMBL1845611 | 0.81 | CYP1A2 (0.41) | CYP2C19FLT3YTHDC1ALDH1A1KMT2A | |
| SCHEMBL2489275 | 0.80 | NPSR1 (0.48) | CYP2C19YTHDC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL14722928 | 0.80 | CYP2C19 (0.43) | CYP2C19FLT3YTHDC1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | disclosed |