Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SGK1 | O00141 | 5/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156157 | 0.79 | LRRK2 (0.46) | LRRK2PDE4DMAPK1KMT2AHSD17B10 | |
| SCHEMBL3263200 | 0.75 | LRRK2 (0.46) | LRRK2HCAR2PDE4DMAPK1KMT2A | |
| SCHEMBL3261441 | 0.75 | LRRK2 (0.46) | LRRK2PDE4DMAPK1KMT2AHSD17B10 | |
| SCHEMBL2724008 | 0.75 | LRRK2 (0.46) | LRRK2PDE4DMAPK1KMT2AHSD17B10 | |
| SCHEMBL16402355 | 0.72 | LRRK2 (0.44) | LRRK2PDE4DMAPK1KMT2AHSD17B10 | |
| SCHEMBL17156270 | 0.71 | HSD17B10 (0.43) | LRRK2PDE4DMAPK1KMT2AHSD17B10 | |
| Hydrochloric Acid SCHEMBL16402448 | 0.71 | LRRK2 (0.42) | LRRK2PDE4DMAPK1KMT2AHSD17B10 | |
| SCHEMBL3260996 | 0.68 | PDE4D (0.69) | LRRK2PDE4DMAPK1KMT2AHTT | |
| SCHEMBL4269650 | 0.68 | LRRK2 (0.40) | LRRK2KDM4E | |
| SCHEMBL3263505 | 0.68 | LRRK2 (0.40) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015657-A2 | NEW ALKOXYPYRAZOLES | INSTITUT PASTEUR (FR) | 2010-02-11 | — | — | WO | disclosed |
| EP-2151433-A1 | Alkoxypyrazoles and the process for their preparation | Institut Pasteur (FR) | 2010-02-10 | — | — | EP | disclosed |
| EP-2151433-A1 | Alkoxypyrazoles and the process for their preparation | Institut Pasteur (FR) | 2010-02-10 | — | — | EP | disclosed |