Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.77 |
| ▸ | JAK3 | P52333 | 8/20 | 0.61 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.61 |
| ▸ | JAK1 | P23458 | 3/20 | 0.58 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3200947 | 0.96 | JAK2 (0.83) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3303044 | 0.95 | JAK2 (0.77) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3210880 | 0.90 | JAK2 (0.78) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3213810 | 0.90 | JAK2 (0.74) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3208915 | 0.90 | JAK2 (0.74) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2145769 | 0.90 | JAK2 (0.64) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2146398 | 0.88 | JAK2 (0.75) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL7977699 | 0.88 | JAK2 (0.71) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144480 | 0.88 | JAK2 (0.64) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3208463 | 0.87 | JAK2 (0.70) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010189-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010189-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |