SCHEMBL3263516

SCHEMBL3263516

O=C(O)N1CCCC(O)(COc2cc(F)cc3ccc(-c4nnc5ccccn45)nc23)CC1

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PIM1 P11309 20/20 0.61
PIM2 Q9P1W9 20/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1980914 0.90 PIM1 (0.58) PIM1PIM2
SCHEMBL1963874 0.90 PIM1 (0.72) PIM1PIM2
SCHEMBL1975851 0.80 PIM1 (0.72) PIM1PIM2
SCHEMBL1973025 0.80 PIM1 (0.66) PIM1PIM2
SCHEMBL1977817 0.78 PIM1 (0.71) PIM1PIM2
SCHEMBL1964602 0.76 PIM1 (0.69) PIM1PIM2
SCHEMBL1976135 0.76 PIM1 (1.00) PIM1PIM2
SCHEMBL1968401 0.76 PIM1 (0.74) PIM1PIM2
SCHEMBL1970907 0.76 PIM1 (1.00) PIM1PIM2
Hydrochloric Acid SCHEMBL1975766 0.75 PIM1 (0.98) PIM1PIM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010022076-A1 TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2010-02-25 WO disclosed