Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 4/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.51 |
| ▸ | CNR2 | P34972 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13521620 | 0.90 | GRIN2B (0.52) | GRIN2BGRIN1CNR2 | |
| SCHEMBL13521624 | 0.90 | GRIN1 (0.49) | GRIN2BGRIN1CNR2POLBTHRB | |
| SCHEMBL3122894 | 0.89 | GRIN1 (0.51) | GRIN2BGRIN1CNR2THRBTP53 | |
| SCHEMBL3129846 | 0.87 | GRIN1 (0.46) | GRIN2BGRIN1CNR2 | |
| SCHEMBL13521717 | 0.87 | GRIN2B (0.49) | GRIN2BGRIN1CNR2POLBTHRB | |
| SCHEMBL13521696 | 0.86 | GRIN2B (0.47) | GRIN2BGRIN1CNR2POLBTHRB | |
| SCHEMBL13521698 | 0.86 | GRIN2B (0.49) | GRIN2BGRIN1CNR2POLBTHRB | |
| SCHEMBL3120603 | 0.86 | GRIN2B (0.45) | GRIN2BGRIN1CNR2THRBTP53 | |
| SCHEMBL3126458 | 0.83 | GRIN2B (0.47) | GRIN2BGRIN1CNR2ALDH1A1 | |
| SCHEMBL3122850 | 0.80 | GRIN1 (0.50) | GRIN2BGRIN1CNR2POLBTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | claimed |
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | disclosed |