Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.49 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247848 | 0.89 | AIMP2 (0.58) | SYKAIMP2SCN9AJAK2HDAC1 | |
| SCHEMBL3254348 | 0.88 | AIMP2 (0.49) | SYKAIMP2SCN9AJAK2HDAC1 | |
| SCHEMBL3247473 | 0.88 | AIMP2 (0.51) | SYKAIMP2NTRK1 | |
| SCHEMBL3254613 | 0.80 | PIK3CA (0.47) | SYKAIMP2 | |
| SCHEMBL3255252 | 0.80 | CDK2 (0.53) | SYKJAK2 | |
| SCHEMBL3250561 | 0.79 | CDK2 (0.56) | SYKJAK2 | |
| SCHEMBL3391948 | 0.78 | AIMP2 (0.51) | SYKAIMP2SCN9AJAK2HDAC1 | |
| SCHEMBL3256070 | 0.78 | AIMP2 (0.59) | SYKAIMP2SCN9AJAK2HDAC1 | |
| SCHEMBL3252685 | 0.74 | FLT3 (0.62) | SYKAIMP2JAK2 | |
| SCHEMBL3249693 | 0.74 | JAK2 (0.59) | SYKAIMP2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521749-B1 | PHENYL-(4-(3-PHENYL-1H-PYRAZOL-4-YL)-PYRIMIDIN-2-Yl)-AMINE DERIVATIVES | NOVARTIS AG (CH) | 2010-05-19 | — | — | EP | claimed |