Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 4/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.42 |
| ▸ | PLK1 | P53350 | 3/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.39 |
| ▸ | NEK2 | P51955 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553560 | 0.83 | PLK1 (0.57) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL3250712 | 0.83 | PLK1 (0.57) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4290573 | 0.82 | CHEK2 (0.41) | CHEK2GPR119PLK1PLK3NEK2 | |
| SCHEMBL3257126 | 0.82 | PLK1 (0.53) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL3254713 | 0.76 | PLK1 (0.49) | GPR119PLK1PLK3NEK2PIK3CD | |
| SCHEMBL3263611 | 0.76 | PLK1 (0.60) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL3256390 | 0.75 | PLK1 (0.60) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL13440232 | 0.75 | PLK1 (0.60) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL3257193 | 0.75 | PLK1 (0.45) | GPR119PLK1PLK3NEK2PIK3CD | |
| SCHEMBL3267248 | 0.75 | PLK1 (0.45) | GPR119PLK1PLK3NEK2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032563-B1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON PLK | GLAXOSMITHKLINE LLC (US) | 2010-06-02 | — | — | EP | disclosed |