Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.60 |
| ▸ | SMPD3 | Q9NY59 | 14/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2178752 | 0.92 | PDE10A (0.63) | PDE10ASMPD3DHODHKMT2AKDM4E | |
| SCHEMBL2178745 | 0.92 | PDE10A (0.63) | PDE10ASMPD3DHODHKMT2AKDM4E | |
| SCHEMBL12408665 | 0.89 | PDE10A (0.57) | PDE10ASMPD3 | |
| SCHEMBL12408662 | 0.88 | PDE10A (0.59) | PDE10ASMPD3 | |
| SCHEMBL2178794 | 0.85 | PDE10A (0.66) | PDE10ASMPD3DHODHKMT2AKDM4E | |
| SCHEMBL2178797 | 0.85 | PDE10A (0.66) | PDE10ASMPD3DHODHKMT2AKDM4E | |
| SCHEMBL2212770 | 0.84 | PDE10A (0.61) | PDE10ASMPD3DHODHKMT2AKDM4E | |
| SCHEMBL2180262 | 0.83 | PDE10A (0.66) | PDE10ASMPD3DHODHKMT2AKDM4E | |
| SCHEMBL2180258 | 0.83 | PDE10A (0.66) | PDE10ASMPD3DHODHKMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL2180625 | 0.83 | PDE10A (0.65) | PDE10ASMPD3DHODHKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342191-B1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-03-20 | — | — | EP | disclosed |
| US-20110166135-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-07-07 | — | — | US | disclosed |
| WO-2010030027-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166135-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | PDE10A, PDE3A, PDE3B | PDE10A 1/4885SMPD3 129/4885DHODH 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.