⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29375650 | 1.00 | — | — | |
| Ammonia Solution, Strong SCHEMBL27798167 | 1.00 | — | — | |
| SCHEMBL29353695 | 1.00 | — | — | |
| SCHEMBL28855 | 1.00 | — | — | |
| SCHEMBL8764947 | 1.00 | — | — | |
| SCHEMBL27704132 | 1.00 | — | — | |
| SCHEMBL29872025 | 1.00 | — | — | |
| SCHEMBL30129268 | 1.00 | — | — | |
| SCHEMBL9998309 | 0.71 | — | — | |
| SCHEMBL22968 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912214-B2 | Use of Chk2 kinase inhibitors for cancer treatment | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2014-12-16 | — | — | US | disclosed |
| EP-1912635-B1 | USE OF CHK2 KINASE INHIBITORS FOR CANCER TREATMENT | US GOV HEALTH & HUMAN SERV (US) | 2014-03-05 | — | — | EP | disclosed |
| US-20100069423-A1 | Use of Chk2 Kinase Inhibitors for Cancer Treatment | GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-03-18 | — | — | US | disclosed |
| EP-1912635-A2 | USE OF CHK2 KINASE INHIBITORS FOR CANCER TREATMENT | The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007016338-A2 | USE OF CHK2 KINASE INHIBITORS FOR CANCER TREATMENT | GOVERMENT OF THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2007-02-08 | — | — | WO | disclosed |
| US-5226405-A | Ignition platform and fuel component for kindling a fire | SNOW GEORGE H (US) | 1993-07-13 | — | — | US | disclosed |