Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.54 |
| ▸ | PLK3 | Q9H4B4 | 13/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | NEK2 | P51955 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3259770 | 1.00 | PLK1 (0.54) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL3255943 | 0.94 | PLK1 (0.51) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL3601523 | 0.92 | PLK1 (0.53) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL3264411 | 0.90 | PLK1 (0.57) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL3256929 | 0.90 | PLK1 (0.57) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL3251961 | 0.89 | PLK1 (0.52) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL3267703 | 0.89 | PLK1 (0.52) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL3253896 | 0.88 | PLK1 (0.50) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL3254887 | 0.88 | PLK1 (0.56) | PLK1PLK3CDK2IKBKEPIK3CD | |
| SCHEMBL4551877 | 0.88 | PLK1 (0.56) | PLK1PLK3CDK2IKBKEPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032563-B1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON PLK | GLAXOSMITHKLINE LLC (US) | 2010-06-02 | — | — | EP | disclosed |