Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.42 |
| ▸ | OGA | O60502 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | ATR | Q13535 | 2/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1028951 | 0.93 | PIK3CA (0.67) | PIK3CAPIK3CBPIK3CGOGAMTOR | |
| SCHEMBL13336824 | 0.92 | PIK3CA (0.65) | PIK3CAPIK3CBPIK3CGNAPEPLDOGA | |
| SCHEMBL1025387 | 0.91 | PIK3CA (0.64) | PIK3CAPIK3CBPIK3CGNAPEPLDOGA | |
| SCHEMBL1027127 | 0.88 | PIK3CA (0.68) | PIK3CAPIK3CBPIK3CGNAPEPLDOGA | |
| SCHEMBL1026996 | 0.88 | PIK3CA (0.68) | PIK3CAPIK3CBPIK3CGNAPEPLDOGA | |
| SCHEMBL1028146 | 0.88 | PIK3CA (0.71) | PIK3CAPIK3CBPIK3CGNAPEPLDOGA | |
| SCHEMBL13336861 | 0.87 | PIK3CA (0.79) | PIK3CAPIK3CBPIK3CGOGAMTOR | |
| SCHEMBL1026999 | 0.86 | PIK3CA (0.65) | PIK3CAPIK3CBPIK3CGNAPEPLDOGA | |
| SCHEMBL1028960 | 0.86 | PIK3CA (0.69) | PIK3CAPIK3CBPIK3CGNAPEPLDOGA | |
| SCHEMBL1026861 | 0.86 | PIK3CA (0.69) | PIK3CAPIK3CBPIK3CGOGARAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150546-A2 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE | F. Hoffmann-Roche AG (CH) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008125839-A2 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE | PIRAMED LIMITED (GB) | 2008-10-23 | — | — | WO | disclosed |