Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.68 |
| ▸ | ACVR2A | P27037 | 12/20 | 0.49 |
| ▸ | TGFBR2 | P37173 | 11/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.49 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2640390 | 0.81 | JAK2 (1.00) | JAK2NUDT1JAK1JAK3 | |
| SCHEMBL3261792 | 0.81 | JAK2 (0.66) | JAK2NUDT1JAK1JAK3 | |
| SCHEMBL1691331 | 0.80 | JAK2 (0.62) | JAK2TGFBR2NUDT1JAK1JAK3 | |
| SCHEMBL1691216 | 0.78 | JAK2 (0.68) | JAK2NUDT1JAK1JAK3 | |
| SCHEMBL2640477 | 0.77 | JAK2 (1.00) | JAK2NUDT1JAK1JAK3 | |
| SCHEMBL13535522 | 0.74 | JAK1 (0.65) | JAK2ACVR2ATGFBR2TGFBR1JAK1 | |
| SCHEMBL18367046 | 0.73 | JAK2 (0.77) | JAK2NUDT1JAK1JAK3 | |
| SCHEMBL2640397 | 0.73 | JAK2 (1.00) | JAK2NUDT1JAK3 | |
| SCHEMBL2257705 | 0.73 | JAK2 (0.64) | JAK2NUDT1JAK1JAK3 | |
| SCHEMBL30042559 | 0.72 | IDO1 (0.48) | ACVR2ATGFBR2TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010186-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |