Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.50 |
| ▸ | ESRRG | P62508 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3241380 | 0.90 | ESR1 (0.66) | ESR1ESR2ESRRGCYP3A4HPGD | |
| SCHEMBL3235254 | 0.90 | ESR1 (0.66) | ESR1ESR2ESRRGCYP3A4HPGD | |
| SCHEMBL29376996 | 0.86 | ESRRG (0.44) | ESR1ESR2ESRRGCYP3A4ALDH1A1 | |
| SCHEMBL6855603 | 0.82 | ESRRG (0.40) | ESR1ESR2ESRRGCYP3A4CYP17A1 | |
| SCHEMBL12446623 | 0.82 | ESR1 (0.52) | ESR1ESRRGCYP3A4ALDH1A1HPGD | |
| SCHEMBL23059324 | 0.81 | ESR1 (0.49) | ESR1ESR2CNR1CNR2AR | |
| SCHEMBL13882014 | 0.80 | ESR1 (0.46) | ESR1ESR2ESRRGALDH1A1HPGD | |
| SCHEMBL25596291 | 0.76 | KDM4E (0.45) | ESRRGCYP3A4ALDH1A1HPGDALOX15 | |
| SCHEMBL13592369 | 0.76 | CYP17A1 (0.42) | ESR1ESR2ESRRGCYP3A4ALDH1A1 | |
| SCHEMBL14047850 | 0.76 | CYP3A4 (0.42) | ESR1ESR2ESRRGCYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010030787-A1 | ESTROGEN RECEPTOR LIGANDS | RADIUS HEALTH, INC. (US) | 2010-03-18 | — | — | WO | claimed |
| WO-2010030787-A1 | ESTROGEN RECEPTOR LIGANDS | RADIUS HEALTH, INC. (US) | 2010-03-18 | — | — | WO | disclosed |