Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | TYK2 | P29597 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 4/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12102775 | 0.89 | JAK2 (0.52) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL1298782 | 0.87 | JAK2 (0.52) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL1299147 | 0.87 | JAK2 (0.51) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL1299128 | 0.86 | JAK2 (0.49) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL12102307 | 0.86 | JAK2 (0.54) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL13521304 | 0.85 | JAK2 (0.50) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL13521286 | 0.85 | JAK2 (0.50) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL1299226 | 0.84 | JAK2 (0.51) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL12102727 | 0.84 | JAK2 (0.49) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL1298478 | 0.84 | JAK2 (0.48) | JAK2CYP3A4CYP2C8CYP2C9JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002472-A1 | JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2010-01-07 | — | — | WO | claimed |