Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1157251 | 0.89 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4CTP53 | |
| SCHEMBL7948752 | 0.87 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4CTP53 | |
| SCHEMBL3129241 | 0.86 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4CTP53 | |
| SCHEMBL1157624 | 0.86 | PDE4A (0.57) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL3192669 | 0.86 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CTP53 | |
| SCHEMBL3126137 | 0.86 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4CGRM2 | |
| SCHEMBL1157609 | 0.86 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4CPDK1 | |
| SCHEMBL1157309 | 0.86 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1157358 | 0.86 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1157497 | 0.86 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | claimed |
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |