SCHEMBL32659848

SCHEMBL32659848

O=c1[nH]c2cc3c(Cl)c(-c4ccc(Cl)nn4)ccc3nc2[nH]1

nearest known ligand 0.60

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 20/20 0.60
PDE3A Q14432 20/20 0.60
PDE2A O00408 3/20 0.49
P2RY12 Q9H244 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32659861 0.80 PDE3B (0.62) PDE3BPDE3APDE2AP2RY12
SCHEMBL32659817 0.78 PDE3B (0.53) PDE3BPDE3APDE2AP2RY12
SCHEMBL32659834 0.77 PDE3B (0.61) PDE3BPDE3APDE2AP2RY12
SCHEMBL32659827 0.77 PDE3B (0.68) PDE3BPDE3APDE2AP2RY12
SCHEMBL32659836 0.76 PDE3B (0.60) PDE3BPDE3APDE2AP2RY12
SCHEMBL32659869 0.76 PDE3B (0.60) PDE3BPDE3APDE2AP2RY12
SCHEMBL10757126 0.75 PDE3B (1.00) PDE3BPDE3APDE2AP2RY12
SCHEMBL32659835 0.74 PDE3B (0.57) PDE3BPDE3APDE2AP2RY12
SCHEMBL32659853 0.74 PDE3B (0.57) PDE3BPDE3APDE2AP2RY12
SCHEMBL32659842 0.71 PDE3B (0.53) PDE3BPDE3APDE2AP2RY12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4678641-A1 QUINOLINONE COMPOUND AND NAPHTHYRIDINONE COMPOUND AND USE THEREOF Shanghai Helioson Pharmaceutical Co., Ltd. (CN) 2026-01-14 EP disclosed