Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.33 |
| ▸ | CETP | P11597 | 3/20 | 0.33 |
| ▸ | GMNN | O75496 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2835408 | 0.89 | — | — | |
| SCHEMBL6432081 | 0.79 | TSHR (0.82) | TSHRALDH1A1MAPTLMNAUSP2 | |
| SCHEMBL28897337 | 0.77 | TSHR (0.78) | TSHRALDH1A1MAPTLMNAUSP2 | |
| SCHEMBL9187603 | 0.77 | TSHR (0.78) | TSHRALDH1A1MAPTLMNAUSP2 | |
| SCHEMBL22323638 | 0.77 | TSHR (0.78) | TSHRALDH1A1MAPTLMNAUSP2 | |
| SCHEMBL25178050 | 0.77 | TSHR (0.78) | TSHRALDH1A1MAPTLMNAUSP2 | |
| SCHEMBL630278 | 0.77 | TSHR (0.78) | TSHRALDH1A1MAPTLMNAUSP2 | |
| SCHEMBL7856670 | 0.77 | TSHR (0.78) | TSHRALDH1A1MAPTLMNAUSP2 | |
| SCHEMBL2405672 | 0.76 | TSHR (1.00) | TSHRALDH1A1MAPTLMNATHRB | |
| SCHEMBL9420916 | 0.76 | TSHR (1.00) | TSHRALDH1A1MAPTLMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |
| EP-2168952-A1 | MORPHOLINE DERIVATIVE | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-03-31 | — | — | EP | disclosed |