Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819089 | 0.83 | KCNH2 (0.40) | KDM4EALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL9818809 | 0.83 | DRD4 (0.43) | POLQKDM4EHSD17B10ALDH1A1RAB9A | |
| SCHEMBL15650622 | 0.83 | PPIB (0.43) | KDM4EALDH1A1RAB9AMAPTLMNA | |
| SCHEMBL11209904 | 0.82 | KMT2A (0.52) | POLQALDH1A1RAB9ALMNAKMT2A | |
| SCHEMBL9819119 | 0.82 | POLQ (0.48) | POLQLMNASMN1; SMN2 | |
| SCHEMBL2086812 | 0.81 | GPBAR1 (0.40) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL9819029 | 0.79 | GPBAR1 (0.42) | LMNAKMT2A | |
| SCHEMBL8443795 | 0.78 | POLQ (0.49) | POLQKDM4EGAAFOLH1HSD17B10 | |
| SCHEMBL13041524 | 0.78 | POLQ (0.49) | POLQKDM4EGAAFOLH1HSD17B10 | |
| SCHEMBL2088005 | 0.78 | MAPT (0.40) | GAAALDH1A1RAB9AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740171-B1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-06-09 | — | — | EP | disclosed |