SCHEMBL32668360

SCHEMBL32668360

NCc1cccc(C(=O)N2CCC(O)(Cn3cnc4c(cnn4-c4ccccc4)c3=O)CC2)c1

nearest known ligand 0.57

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
USP7 Q93009 17/20 0.57
LMNA P02545 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
KDM4E B2RXH2 1/20 0.50
HPGD P15428 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17870052 1.00 USP7 (0.57) USP7LMNASMN1; SMN2KDM4EHPGD
SCHEMBL17870506 0.93 USP7 (0.60) USP7SMN1; SMN2
SCHEMBL17869587 0.93 USP7 (0.58) USP7LMNASMN1; SMN2KDM4EHPGD
SCHEMBL17894617 0.90 USP7 (0.58) USP7LMNA
SCHEMBL32668357 0.90 USP7 (0.58) USP7LMNA
SCHEMBL32668304 0.90 USP7 (0.58) USP7LMNA
SCHEMBL17894887 0.90 USP7 (0.58) USP7LMNA
SCHEMBL17869336 0.90 USP7 (0.65) USP7LMNA
SCHEMBL17869721 0.89 USP7 (0.59) USP7LMNA
SCHEMBL17870238 0.89 USP7 (0.58) USP7LMNASMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3623372-B1 PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS VALO HEALTH INC (US) 2026-02-04 EP claimed