Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3268910 | 0.88 | HPGD (0.45) | TLR9TLR7TRPV3CDK2NPC1 | |
| SCHEMBL4662880 | 0.83 | BRD4 (0.50) | BRD4LRRK2NPC1HPGDRAB9A | |
| SCHEMBL30501981 | 0.81 | BRD4 (0.48) | BRD4LRRK2NPC1HPGDRAB9A | |
| SCHEMBL4666497 | 0.80 | BRD4 (0.47) | BRD4LRRK2NPC1HPGDRAB9A | |
| SCHEMBL3267586 | 0.78 | AURKA (0.40) | TLR9CDK2AURKANR1H2CCNA2 | |
| SCHEMBL1942215 | 0.77 | BRD4 (0.44) | BRD4LRRK2HPGDSMN1; SMN2CYP2C9 | |
| SCHEMBL4664610 | 0.76 | BRD4 (0.47) | BRD4LRRK2NPC1HPGDRAB9A | |
| SCHEMBL4662927 | 0.75 | BRD4 (0.48) | BRD4LRRK2NPC1HPGDRAB9A | |
| SCHEMBL4664584 | 0.75 | BRD4 (0.43) | BRD4LRRK2NPC1HPGDRAB9A | |
| SCHEMBL4663172 | 0.75 | BRD4 (0.47) | BRD4LRRK2NPC1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963311-B1 | CHROMANE SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS ACID PUMP INHIBITORS | RAQUALIA PHARMA INC (JP) | 2010-06-16 | — | — | EP | disclosed |
| US-7723321-B2 | Chromane substituted benzimidazole derivatives | RAQUALIA PHARMA INC. (JP) | 2010-05-25 | — | — | US | disclosed |
| US-20070142448-A1 | Chromane Substituted Benzimidazole Derivatives | PFIZER INC. | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142448-A1 | Chromane Substituted Benzimidazole Derivatives | HRH2, HRH4, HRH1 | BRD4 299/4885TLR9 487/4885TLR7 770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.