Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 17/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 15/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175935 | 0.84 | MCHR1 (0.65) | MCHR1KCNH2HRH3 | |
| SCHEMBL163159 | 0.79 | MCHR1 (0.62) | MCHR1KCNH2HRH3 | |
| SCHEMBL8840247 | 0.78 | PTPN1 (0.68) | NPC1RAB9AKMT2A | |
| SCHEMBL17328846 | 0.78 | MCHR1 (0.60) | MCHR1KCNH2HRH3 | |
| SCHEMBL11222701 | 0.77 | NPC1 (0.58) | NPC1RAB9AKMT2A | |
| SCHEMBL30968135 | 0.77 | NPC1 (0.61) | NPC1RAB9AKMT2A | |
| SCHEMBL163155 | 0.77 | MCHR1 (0.70) | MCHR1KCNH2HRH3 | |
| SCHEMBL322320 | 0.74 | MCHR1 (1.00) | MCHR1KCNH2HRH3 | |
| SCHEMBL13004548 | 0.74 | NPC1 (0.85) | NPC1RAB9AKMT2A | |
| SCHEMBL30968155 | 0.73 | SMPD1 (0.61) | NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590969-A2 | THERAPEUTIC AGENTS 976 | AstraZeneca AB (SE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004588-A2 | THERAPEUTIC AGENTS 976 | ASTRAZENECA AB (SE) | 2012-01-12 | — | — | WO | disclosed |