SCHEMBL32679148

SCHEMBL32679148

NC(=O)c1ccc(-c2noc(C(F)(F)F)n2)cc1-c1ccccc1F

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.56
RAB9A P51151 4/20 0.56
HDAC6 Q9UBN7 13/20 0.54
HDAC1 Q13547 8/20 0.54
HDAC8 Q9BY41 5/20 0.54
HDAC4 P56524 10/20 0.51
HDAC5 Q9UQL6 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32679146 1.00 NPC1 (0.56) NPC1RAB9AHDAC6HDAC1HDAC8
SCHEMBL29598891 0.89 HDAC6 (0.51) NPC1RAB9AHDAC6HDAC1HDAC8
SCHEMBL21806679 0.89 HDAC6 (0.58) NPC1RAB9AHDAC6HDAC1HDAC8
SCHEMBL29598564 0.85 HDAC6 (0.55) NPC1RAB9AHDAC6HDAC1HDAC8
SCHEMBL29625964 0.85 HDAC4 (0.64) HDAC6HDAC1HDAC8HDAC4
SCHEMBL29598584 0.83 HDAC6 (0.49) NPC1RAB9AHDAC6HDAC1HDAC8
SCHEMBL29598171 0.83 HDAC6 (0.51) NPC1RAB9AHDAC6HDAC1HDAC8
SCHEMBL29598890 0.81 HDAC6 (0.51) NPC1RAB9AHDAC6HDAC1HDAC8
SCHEMBL29465516 0.81 HDAC6 (0.51) NPC1RAB9AHDAC6HDAC1HDAC8
SCHEMBL29598593 0.81 HDAC4 (0.60) HDAC6HDAC1HDAC8HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4114183-B1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2026-02-25 EP disclosed