Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.59 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 18/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 18/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 17/20 | 0.58 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.51 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.51 |
| ▸ | PI4KA | P42356 | 1/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3269557 | 0.88 | PIK3CD (0.66) | PIK3CDPIK3C3PIK3CBPIK3CGPIK3CA | |
| SCHEMBL925661 | 0.88 | PIK3CD (0.65) | PIK3CDPIK3C3PIK3CBPIK3CGPIK3CA | |
| SCHEMBL925319 | 0.88 | PIK3CD (0.60) | PIK3CDPIK3C3PIK3CBPIK3CGPIK3CA | |
| SCHEMBL926038 | 0.87 | PIK3CD (0.75) | PIK3CDPIK3C3PIK3CBPIK3CGPIK3CA | |
| SCHEMBL927078 | 0.87 | PIK3CD (0.71) | PIK3CDPIK3C3PIK3CBPIK3CGPIK3CA | |
| SCHEMBL924991 | 0.85 | PIK3CD (0.61) | PIK3CDPIK3C3PIK3CBPIK3CGPIK3CA | |
| SCHEMBL926035 | 0.83 | PIK3CD (0.62) | PIK3CDPIK3C3PIK3CBPIK3CGPIK3CA | |
| SCHEMBL924531 | 0.83 | PIK3CD (0.58) | PIK3CDPIK3C3PIK3CBPIK3CGPIK3CA | |
| SCHEMBL924743 | 0.82 | PIK3CB (0.68) | PIK3CDPIK3C3PIK3CBPIK3CGPIK3CA | |
| SCHEMBL925874 | 0.81 | PIK3CD (0.61) | PIK3CDPIK3C3PIK3CBPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841763-B1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS PI3K INHIBITORS | ASTRAZENECA AB (SE) | 2010-06-30 | — | — | EP | disclosed |