Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.63 |
| ▸ | PDE4A | P27815 | 3/20 | 0.63 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.63 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30123181 | 0.89 | PDE10A (0.79) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL3271199 | 0.89 | PDE10A (0.79) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL30123112 | 0.89 | PDE10A (0.79) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL3270154 | 0.89 | PDE10A (0.79) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL1423719 | 0.86 | PDE10A (0.73) | PDE10A | |
| SCHEMBL4162900 | 0.85 | PDE10A (0.73) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL3272173 | 0.83 | PDE10A (0.64) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL30123176 | 0.83 | PDE10A (0.64) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL4870859 | 0.81 | PDE10A (0.86) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL188012 | 0.78 | PDE10A (0.63) | PDE10APDE4BPDE4APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841757-B1 | HETEROAROMATIC QUINOLINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | PFIZER PROD INC (US) | 2010-06-30 | — | — | EP | disclosed |