Sugi Predict

Sugi Predict / Compounds / SCHEMBL3269984

SCHEMBL3269984

SCHEMBL3269984

CCc1ccc(/C(=C\CSc2ccc(OCC(=O)O)c(Cl)c2)c2ccccc2)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PPARD Q03181 7/20 0.72
▸ TDP1 Q9NUW8 3/20 0.43
▸ TSHR P16473 1/20 0.43
▸ PPARA Q07869 1/20 0.42
▸ CYP2C19 P33261 1/20 0.42
▸ PTPN7 P35236 1/20 0.42
▸ DUSP3 P51452 1/20 0.42
▸ PTPN12 Q05209 1/20 0.42
▸ PTPN22 Q9Y2R2 1/20 0.42
▸ LTB4R Q15722 2/20 0.39
▸ LTB4R2 Q9NPC1 2/20 0.39
▸ PTGDR2 Q9Y5Y4 3/20 0.38
▸ LMNA P02545 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ HPGD P15428 1/20 0.38
▸ HTT P42858 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3269988 1.00 PPARD (0.72) PPARDTDP1TSHRPPARACYP2C19
SCHEMBL3275139 0.97 PPARD (0.77) PPARDTDP1TSHRPPARACYP2C19
SCHEMBL3271226 0.92 PPARD (0.67) PPARDTDP1TSHRPPARACYP2C19
SCHEMBL3268838 0.92 PPARD (0.67) PPARDTDP1TSHRPPARACYP2C19
SCHEMBL3269679 0.90 PPARD (0.66) PPARDTDP1TSHRPPARACYP2C19
SCHEMBL3269735 0.90 PPARD (0.75) PPARDTDP1TSHRPPARACYP2C19
SCHEMBL3269738 0.90 PPARD (0.75) PPARDTDP1TSHRPPARACYP2C19
SCHEMBL3269925 0.89 PPARD (0.78) PPARDTDP1TSHRPPARACYP2C19
SCHEMBL3276628 0.89 PPARD (0.78) PPARDTDP1TSHRPPARACYP2C19
SCHEMBL3268426 0.89 PPARD (0.71) PPARDTDP1TSHRPPARACYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1558572-B1 NOVEL COMPOUNDS AND THEIR USE AS PRAR-MODULATORS HIGH POINT PHARMACEUTICALS LLC (US) 2010-06-30 — — EP claimed
US-7129268-B2 Peroxisome proliferator activated receptor-active arylene acetic acid derivatives NOVO NORDISK A/S (DK) 2006-10-31 — — US claimed
US-20050070583-A1 Novel compounds, their preparation and use VTVX HOLDINGS II LLC 2005-03-31 — — US claimed
EP-1558572-B1 NOVEL COMPOUNDS AND THEIR USE AS PRAR-MODULATORS HIGH POINT PHARMACEUTICALS LLC (US) 2010-06-30 — — EP disclosed
US-7129268-B2 Peroxisome proliferator activated receptor-active arylene acetic acid derivatives NOVO NORDISK A/S (DK) 2006-10-31 — — US disclosed
EP-1558572-A2 NOVEL COMPOUNDS AND THEIR USE AS PRAR-MODULATORS NOVO NORDISK A/S (DK) 2005-08-03 — — EP disclosed
US-20050070583-A1 Novel compounds, their preparation and use VTVX HOLDINGS II LLC 2005-03-31 — — US disclosed
WO-2004037776-A2 NOVEL COMPOUNDS AND THEIR USE AS PRAR-MODULATORS NOVO NORDISK A/S (DK) 2004-05-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050070583-A1 Novel compounds, their preparation and use PPARG, PPARD, PPARA PPARD 2/4885TDP1 3789/4885TSHR 1081/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.