Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4448579 | 0.90 | GBA1 (0.46) | TACR1AGTR2SIGMAR1 | |
| SCHEMBL8925928 | 0.78 | TACR1 (0.50) | TACR1CCR3 | |
| SCHEMBL8925926 | 0.78 | TACR1 (0.50) | TACR1CCR3 | |
| SCHEMBL3652328 | 0.78 | TACR1 (0.50) | TACR1CCR3 | |
| SCHEMBL6027066 | 0.76 | TACR1 (0.48) | TACR1PRMT3CARM1PRMT6PRMT1 | |
| SCHEMBL18640230 | 0.76 | TACR1 (0.48) | TACR1PRMT3CARM1PRMT6PRMT1 | |
| SCHEMBL7854892 | 0.76 | TACR1 (0.63) | TACR1HSD11B1 | |
| SCHEMBL18640284 | 0.75 | TACR1 (0.47) | TACR1 | |
| SCHEMBL18640360 | 0.74 | TACR1 (0.46) | TACR1SIGMAR1 | |
| SCHEMBL18640236 | 0.74 | TACR1 (0.49) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200982-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009033995-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-03-19 | — | — | WO | disclosed |