Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 20/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 13/20 | 0.52 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL326746 | 1.00 | S1PR5 (0.52) | S1PR5S1PR1S1PR3 | |
| SCHEMBL326661 | 1.00 | S1PR5 (0.52) | S1PR5S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL325820 | 0.99 | S1PR5 (0.53) | S1PR5S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL326559 | 0.99 | S1PR5 (0.53) | S1PR5S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL326171 | 0.99 | S1PR5 (0.53) | S1PR5S1PR1S1PR3 | |
| SCHEMBL326923 | 0.92 | S1PR5 (0.44) | S1PR5S1PR1S1PR3 | |
| SCHEMBL326473 | 0.92 | S1PR5 (0.44) | S1PR5S1PR1S1PR3 | |
| SCHEMBL326965 | 0.92 | S1PR5 (0.44) | S1PR5S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL326540 | 0.91 | S1PR5 (0.45) | S1PR5S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL326118 | 0.91 | S1PR5 (0.45) | S1PR5S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590955-B9 | SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS | ABBVIE BV (NL) | 2017-02-22 | — | — | EP | claimed |
| EP-2590955-B1 | SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS | ABBVIE BV (NL) | 2016-10-12 | — | — | EP | claimed |
| EP-2590955-A1 | SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS | ABBVIE B.V. (NL) | 2013-05-15 | — | — | EP | claimed |
| WO-2012004378-A1 | SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS | ABBOTT HEALTHCARE PRODUCTS B.V. (NL) | 2012-01-12 | — | — | WO | claimed |