Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.90 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | PRKCA | P17252 | 4/20 | 0.64 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.64 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.64 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.64 |
| ▸ | DGKA | P23743 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.55 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.55 |
| ▸ | LPAR4 | Q99677 | 1/20 | 0.55 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.55 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.55 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.55 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol Monostearate SCHEMBL11589103 | 1.00 | MAPT (0.90) | MAPTLMNAKDM4EDUSP3MEN1 | |
| Propylene Glycol SCHEMBL709153 | 1.00 | MAPT (0.90) | MAPTLMNAKDM4EDUSP3MEN1 | |
| Propylene Glycol Monostearate SCHEMBL28235626 | 0.95 | MAPT (0.81) | MAPTLMNAKDM4EDUSP3MEN1 | |
| SCHEMBL29649070 | 0.95 | MAPT (1.00) | MAPTLMNAKDM4EDUSP3MEN1 | |
| Propylene Glycol Monostearate SCHEMBL35521 | 0.95 | MAPT (1.00) | MAPTLMNAKDM4EDUSP3MEN1 | |
| SCHEMBL629794 | 0.95 | MAPT (1.00) | MAPTLMNAKDM4EDUSP3MEN1 | |
| SCHEMBL1730481 | 0.95 | MAPT (1.00) | MAPTLMNAKDM4EDUSP3MEN1 | |
| SCHEMBL180498 | 0.95 | MAPT (1.00) | MAPTLMNAKDM4EDUSP3MEN1 | |
| SCHEMBL26974 | 0.95 | MAPT (1.00) | MAPTLMNAKDM4EDUSP3MEN1 | |
| SCHEMBL16458 | 0.95 | MAPT (1.00) | MAPTLMNAKDM4EDUSP3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100086592-A1 | MODIFIED DOSAGE FORMS OF TACROLIMUS | PANACEA BIOTEC LIMITED. (IN) | 2010-04-08 | — | — | US | disclosed |
| WO-2009022354-A2 | MODIFIED DOSAGE FORMS OF TACROLIMUS | PANACEA BIOTEC LIMITED. (IN) | 2009-02-19 | — | — | WO | disclosed |
| EP-1974722-A2 | Modified dosage forms of tacrolimus | Panacea Biotec Ltd (IN) | 2008-10-01 | — | — | EP | disclosed |