Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 15/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31072343 | 0.92 | TLR7 (0.48) | TLR7TLR8LMNAPOLBHRH2 | |
| SCHEMBL145828 | 0.92 | TLR7 (0.48) | TLR7TLR8LMNAPOLBHRH2 | |
| SCHEMBL31658238 | 0.86 | TLR7 (0.46) | TLR7TLR8LMNAPOLBHRH2 | |
| SCHEMBL12245181 | 0.83 | TLR7 (0.48) | TLR7TLR8LMNAPOLBHRH2 | |
| SCHEMBL14141740 | 0.82 | TLR7 (0.37) | TLR7TLR8L3MBTL1 | |
| SCHEMBL31092874 | 0.80 | TLR7 (0.53) | TLR7TLR8L3MBTL1LMNAPOLB | |
| SCHEMBL142572 | 0.80 | TLR7 (0.53) | TLR7TLR8L3MBTL1LMNAPOLB | |
| SCHEMBL20836817 | 0.79 | TLR7 (0.50) | TLR7TLR8LMNAPOLBHRH2 | |
| SCHEMBL3274299 | 0.78 | TLR7 (0.38) | TLR7TLR8LMNAPOLBHRH2 | |
| SCHEMBL147570 | 0.78 | TLR7 (0.54) | TLR7TLR8LMNAPOLBHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2192918-A1 | HIV ENV PROTEINS WITH MODIFICATIONS IN THE V3 LOOP | Novartis Ag (CH) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009029569-A1 | HIV ENV PROTEINS WITH MODIFICATIONS IN THE V3 LOOP | NOVARTIS VACCINES AND DIAGNOSTICS INC. (US) | 2009-03-05 | — | — | WO | disclosed |