⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL313772 | 0.69 | — | — | |
| SCHEMBL2354013 | 0.69 | — | — | |
| SCHEMBL13506266 | 0.69 | — | — | |
| SCHEMBL7699208 | 0.67 | — | — | |
| SCHEMBL4231036 | 0.67 | ABCG2 (0.48) | — | |
| SCHEMBL642467 | 0.67 | — | — | |
| SCHEMBL1144432 | 0.67 | — | — | |
| SCHEMBL20745903 | 0.67 | — | — | |
| SCHEMBL8535551 | 0.67 | — | — | |
| SCHEMBL18108838 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023138691-A1 | FUSED HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAS SIGNALLING | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2023-07-27 | — | — | WO | claimed |
| EP-1940814-B1 | PIPERAZINE DERIVATIVES AS ANTIMALARIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-22 | — | — | EP | claimed |
| US-8067419-B2 | N-[(S)-1-benzyl-2-(4-benzyl-piperazin-1-yl)-2-oxo-ethyl]-N-(4-pentyl-benzyl)-3-(4-trifluoromethyl-phenyl)-acrylamide, for example; antiprotozoa agents | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-11-29 | — | — | US | claimed |
| US-20110136806-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-09 | — | — | US | claimed |
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | UNIVERSITAT DES SAARLANDES (DE) | 2009-09-03 | — | — | US | claimed |
| EP-1330452-B1 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | ORTHO MCNEIL PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |
| CN-101300241-A | Piperazine derivatives as antimalarial agents | ACTELION PHARMACEUTICALS LTD (CH) | 2008-11-05 | — | — | CN | claimed |
| US-20080234272-A1 | Novel Piperazines as Antimalarial Agents | ACTELION PHARMACEUTICALS LTD. (CH) | 2008-09-25 | — | — | US | claimed |
| EP-1940814-A1 | PIPERAZINE DERIVATIVES AS ANTIMALARIAL AGENTS | Actelion Pharmaceuticals Ltd. (CH) | 2008-07-09 | — | — | EP | claimed |
| WO-2007046075-A1 | PIPERAZINE DERIVATIVES AS ANTIMALARIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-04-26 | — | — | WO | claimed |
| US-6710048-B2 | SELECTIVE INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASE; TO TREAT SOLID-TUMOR CANCERS, ANGIOGENESIS, DIABETIC RETINOPATHY, RHEUMATOID ARTHRITIS, ENDOMETRIOSIS AND PSORIASIS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-03-23 | — | — | US | claimed |
| EP-1330452-A2 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-07-30 | — | — | EP | claimed |
| US-20030060629-A1 | Pyrazine derivatives as modulators of tyrosine kinases | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-03-27 | — | — | US | claimed |
| WO-2002024681-A2 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-03-28 | — | — | WO | claimed |
| WO-1998022151-A1 | TRACE CAPTURE IN BIOLOGICAL FLUIDS | SHANBROM EDWARD (US) | 1998-05-28 | — | — | WO | claimed |
| EP-0533244-B1 | Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists | MERCK & CO INC (US) | 1997-12-17 | — | — | EP | claimed |
| EP-0114658-B1 | ALKYL-SUBSTITUTED 4-METHYL-PIPERIDINE DERIVATIVES AND USE THEREOF AS STABILIZERS | AUSIMONT S.p.A. (IT) | 1988-07-27 | — | — | EP | claimed |
| WO-2023138691-A1 | FUSED HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAS SIGNALLING | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2023-07-27 | — | — | WO | disclosed |
| WO-1998022151-A1 | TRACE CAPTURE IN BIOLOGICAL FLUIDS | SHANBROM EDWARD (US) | 1998-05-28 | — | — | WO | disclosed |
| EP-0114658-B1 | ALKYL-SUBSTITUTED 4-METHYL-PIPERIDINE DERIVATIVES AND USE THEREOF AS STABILIZERS | AUSIMONT S.p.A. (IT) | 1988-07-27 | — | — | EP | disclosed |