Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 16/20 | 0.52 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3281650 | 1.00 | GRM5 (0.52) | GRM5MAP3K14PRKD1 | |
| SCHEMBL3276329 | 0.87 | GRM5 (0.51) | GRM5 | |
| SCHEMBL3373517 | 0.87 | GRM5 (0.51) | GRM5 | |
| SCHEMBL1899365 | 0.87 | GRM5 (0.51) | GRM5 | |
| SCHEMBL1897459 | 0.86 | GRM5 (0.56) | GRM5 | |
| SCHEMBL2813707 | 0.86 | GRM5 (0.56) | GRM5 | |
| SCHEMBL3281658 | 0.83 | GRM5 (0.50) | GRM5 | |
| SCHEMBL3277834 | 0.83 | GRM5 (0.50) | GRM5 | |
| SCHEMBL3799474 | 0.82 | GRM5 (0.47) | GRM5 | |
| SCHEMBL4880266 | 0.80 | GRM5 (0.53) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099682-A1 | ACETYLENE DERIVATIVES | NOVARTIS AG | 2010-04-22 | — | — | US | disclosed |
| US-7696379-B2 | Acetylene derivatives | NOVARTIS AG (CH) | 2010-04-13 | — | — | US | disclosed |
| US-20080214673-A1 | Acetylene Derivatives | NOVARTIS AG (CH) | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099682-A1 | ACETYLENE DERIVATIVES | NAT1, NAT10, F12 | GRM5 3794/4885MAP3K14 1709/4885PRKD1 2128/4885 |
| US-20080214673-A1 | Acetylene Derivatives | NAT1, NAT10, F12 | GRM5 3794/4885MAP3K14 1709/4885PRKD1 2128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.