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SCHEMBL3280138

SCHEMBL3280138

CC1(C)Oc2ccc(Nc3nc(Nc4ccc5cn[nH]c5c4)nc4[nH]ccc34)cc2NC1=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 8/20 0.47
▸ JAK1 P23458 2/20 0.47
▸ JAK3 P52333 2/20 0.47
▸ EGFR P00533 1/20 0.38
▸ PDGFRB P09619 3/20 0.38
▸ PDGFRA P16234 3/20 0.38
▸ ROCK1 Q13464 2/20 0.38
▸ ROCK2 O75116 1/20 0.38
▸ EIF2AK2 P19525 1/20 0.38
▸ CDC7 O00311 1/20 0.38
▸ PTK2 Q05397 3/20 0.38
▸ DAPK3 O43293 1/20 0.37
▸ JAK2 O60674 1/20 0.37
▸ PAK4 O96013 1/20 0.37
▸ ABL1 P00519 1/20 0.37
▸ LCK P06239 1/20 0.37
▸ FYN P06241 1/20 0.37
▸ RET P07949 1/20 0.37
▸ PIM1 P11309 1/20 0.37
▸ LTK P29376 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13386794 0.90 SYK (0.53) SYKJAK1JAK3PTK2JAK2
SCHEMBL2105369 0.82 SYK (0.68) SYKJAK1JAK3EGFRPDGFRB
SCHEMBL2104371 0.82 SYK (0.68) SYKJAK1JAK3EGFRPDGFRB
SCHEMBL3278287 0.82 CDC7 (0.52) SYKEGFRPDGFRBPDGFRAROCK1
SCHEMBL3280818 0.80 SYK (0.45) SYKJAK1JAK3EGFR
SCHEMBL14547726 0.79 SYK (0.69) SYKJAK1JAK3EGFRPDGFRB
SCHEMBL12085401 0.77 CCNK (0.46) SYKEGFRPDGFRBPDGFRAROCK1
SCHEMBL3286208 0.76 CDC7 (0.45) SYKEGFRPDGFRBPDGFRAROCK1
SCHEMBL3286011 0.76 PLK4 (0.50) SYKJAK1JAK3EGFRPDGFRB
SCHEMBL3280878 0.76 CDC7 (0.47) SYKEGFRPDGFRBPDGFRAROCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7705004-B2 Protein kinase inhibitors PORTOLA PHARMACEUTICALS, INC. (US) 2010-04-27 — — US claimed
US-20090054425-A1 PROTEIN KINASE INHIBITORS PORTOLA PHARMACEUTICALS, INC. (US) 2009-02-26 — — US claimed
US-7705004-B2 Protein kinase inhibitors PORTOLA PHARMACEUTICALS, INC. (US) 2010-04-27 — — US disclosed
US-7705004-B2 Protein kinase inhibitors PORTOLA PHARMACEUTICALS, INC. (US) 2010-04-27 — — US disclosed
US-7705004-B2 Protein kinase inhibitors PORTOLA PHARMACEUTICALS, INC. (US) 2010-04-27 — — US disclosed
WO-2009026107-A1 PROTEIN KINASE INHIBITORS PORTOLA PHARMACEUTICALS, INC. (US) 2009-02-26 — — WO disclosed
US-20090054425-A1 PROTEIN KINASE INHIBITORS PORTOLA PHARMACEUTICALS, INC. (US) 2009-02-26 — — US disclosed
US-20090054425-A1 PROTEIN KINASE INHIBITORS PORTOLA PHARMACEUTICALS, INC. (US) 2009-02-26 — — US disclosed
US-20090054425-A1 PROTEIN KINASE INHIBITORS PORTOLA PHARMACEUTICALS, INC. (US) 2009-02-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090054425-A1 PROTEIN KINASE INHIBITORS SYK, JAK2, BTK SYK 1/4885JAK1 4/4885JAK3 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.